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In women taking steroids for other conditions (not IBD), an increase in maternal pregnancy complications (such as high blood pressure and diabetes) have occasionally been seen. "The effect on pregnancy outcome, while still uncertain, needs to be considered before considering the possible benefits of using testosterone alone in women with IBD," say the researchers in a paper published online today on PLoS Medicine. The researchers tested 29 women with IBD for maternal drug use including steroid use and their pregnancy outcomes. Of these, nine women in the testosterone group had pregnancies but none of the other women did. Nine of the nine who did not have any birth outcomes, including one who became terminally ill and died prematurely, were also found to have pregnant women present during hospitalization. The findings are based on a retrospective review of medical records of the women before they were diagnosed with IBD in July 2014. They showed an unusually high number of women taking steroids in these cases, suggesting they may have an impact on pregnancy outcomes for some women. It's not clear how common the impact of steroid use on pregnancy outcomes are, but it could be due to the fact that steroid use can result in an increase in appetite associated with weight loss. To see if it was the steroid that was affecting the pregnancy outcomes, the researchers used information provided by the women from their hospital records. They also analysed ultrasound scans made by the women's doctors, taking their height and weight with them to estimate their weight at conception. After taking account of weight loss and changes in appetite during pregnancy, the researchers found that all the women who started steroid therapy during pregnancy had pregnancy outcomes that were significantly worse or identical to those of the nine women who did not have these complications during pregnancy. In contrast, the seven women in the estrogen group who ended their steroid therapies also had pregnancy outcomes that were better. All five patients in the testosterone group had a reduced risk of miscarriage, which may be due to a lower frequency of ectopic pregnancy which is found in people taking steroids. While it is too soon to know the true impact of steroids on pregnancy outcomes, the researchers say their findings should raise a number of questions for healthcare providers and policy makers. "The results of this systematic review suggest that women with IBD who use steroids or steroids-like drugs should be counseled about their pregnancy risks," said co-author Dr Mark S. Wain, a physician and associate professor at the University of Pittsburgh School of Medicine and Dentistry. "It is important to note that the results in this study were from retrospective cohort studies and therefore, although the results of this study may Similar articles: